Takeda Eiji, Yamanaka-Okumura Hisami, Taketani Yutaka, Inagaki Nobuya, Hosokawa Masaya, Shide Kenichiro, Maegawa Hiroshi, Kondo Keiko, Kawasaki Eiji, Shinozaki Shoko, Fujinaka Yuichi, Matsubara Tsukasa, Katayama Takafumi, Sasaki Hajime, Kawashima Akihiro, Aonuma Hiromitsu
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
J Clin Biochem Nutr. 2015 Sep;57(2):140-4. doi: 10.3164/jcbn.14-132. Epub 2015 Aug 6.
The isomaltulose based liquid formula (MHN-01), suppresses postprandial plasma glucose and insulin levels in healthy persons and patients with impaired glucose tolerance (IGT) or type 2 diabetes. MHN-01 intake as a part of breakfast also suppresses glucose and insulin levels after lunch, suggesting second meal effect. The objective of this study was to investigate the effects of nutritional counseling and long-term (24 weeks) MHN-01 ingestion on biomarkers of metabolic syndrome. Forty-one subjects with criteria of metabolic syndrome participated in this study composed with the control period (0-12 week) followed by nutritional counseling and the experimental period (12-36 week) followed by 200 kcal (837 kJ) of MHN-01 or dextrin-based standard balanced liquid formula (SBF) loading as a part of breakfast. In 16 of 41 subjects became to out of criteria for liquid formula loading study during control period (unqualified group). In the unqualified group, several biomarkers were improved. In experimental period, serum HbA1c levels significantly increased in SBF group (n = 12) but did not change in MHN-01 group (n = 10). Thus, intake of 837 kJ MHN-01 as a part of breakfast may be effective for suppression of deteriorating glucose metabolism in metabolic syndrome.
基于异麦芽酮糖醇的液体配方（MHN-01）可降低健康人以及糖耐量受损（IGT）或2型糖尿病患者餐后的血浆葡萄糖和胰岛素水平。将MHN-01作为早餐的一部分摄入，还可降低午餐后的葡萄糖和胰岛素水平，提示存在第二餐效应。本研究的目的是调查营养咨询和长期（24周）摄入MHN-01对代谢综合征生物标志物的影响。41名符合代谢综合征标准的受试者参与了本研究，研究分为对照期（0 - 12周），之后进行营养咨询，以及实验期（12 - 36周），之后将200千卡（837千焦）的MHN-01或基于糊精的标准平衡液体配方（SBF）作为早餐的一部分摄入。41名受试者中有16名在对照期内不符合液体配方摄入研究的标准（不合格组）。在不合格组中，几种生物标志物有所改善。在实验期，SBF组（n = 12）的血清糖化血红蛋白水平显著升高，而MHN-01组（n = 10）则无变化。因此，将837千焦的MHN-01作为早餐的一部分摄入，可能对抑制代谢综合征患者葡萄糖代谢恶化有效。
