Department of Psychology, Louisiana State University, Baton Rouge, LA 70803, United States.
Res Dev Disabil. 2011 Sep-Oct;32(5):1646-51. doi: 10.1016/j.ridd.2011.02.015. Epub 2011 Apr 1.
Seizures are fairly common in those with intellectual disabilities. In order to treat these seizures, antiepileptic drugs (AEDs) are often used and in many cases are effective. However, these medications often create a variety of associated side effects. In order to monitor these side effects, measures such as the SEIZES-B have been used. While many side effects have been found to occur with the use of AEDs, research has not explored if certain side effects are more likely to co-occur. For the current study, 281 people with intellectual disability were administered the SEIZES-B to monitor side effects associated with AEDs. Correlations between side effect subscales were then computed. Several subscales were found to be significantly correlated: hepatic disturbance with dermatological changes and cognitive disturbance; respiratory disturbance with dermatological changes, sedation, and electrolyte disturbance; and cognitive disturbance with sedation and dermatological disturbance. Possible implications of these findings are discussed.
癫痫发作在智力障碍者中较为常见。为了治疗这些癫痫发作，通常会使用抗癫痫药物 (AEDs)，而且在很多情况下都很有效。然而，这些药物常常会产生各种相关的副作用。为了监测这些副作用，人们使用了 SEIZES-B 等措施。虽然已经发现 AEDs 使用过程中会出现许多副作用，但研究尚未探讨某些副作用是否更有可能同时发生。在当前的研究中，对 281 名智力障碍者进行了 SEIZES-B 测试，以监测与 AED 相关的副作用。然后计算了副作用子量表之间的相关性。发现几个子量表显著相关：肝紊乱与皮肤变化和认知障碍相关；呼吸紊乱与皮肤变化、镇静和电解质紊乱相关；认知障碍与镇静和皮肤障碍相关。讨论了这些发现的可能意义。
