DESIR 队列研究：法国早期炎症性背痛 10 年随访：708 例入组患者的研究设计和基线特征。

The DESIR cohort: a 10-year follow-up of early inflammatory back pain in France: study design and baseline characteristics of the 708 recruited patients.

机构信息

Paris-Descartes University, Medicine Faculty, Rheumatology B Department, Paris 14, France.

出版信息

Joint Bone Spine. 2011 Dec;78(6):598-603. doi: 10.1016/j.jbspin.2011.01.013. Epub 2011 Mar 31.

DOI:10.1016/j.jbspin.2011.01.013

PMID:21458351

Abstract

OBJECTIVES

The French Society of Rheumatology has initiated a large national multicenter, longitudinal, prospective follow-up of patients presenting with early inflammatory back pain in order to set up a database to facilitate several investigations on diagnosis, prognosis, epidemiology, pathogenesis and medico-economics in the field of early inflammatory back pain and spondyloarthritis.

METHODS

Patients were recruited if they had inflammatory back pain of more than 3 months and less than 3 years. Patients will be followed every 6 months during the first 2 years then every year during at least 5years. Apart from information collected on a Case Report Form (demographics, disease activity, severity, co-morbidities, socio-economics, treatments, radiological and MRI evaluation of the spine and the pelvis according to the local investigators, and for some centers bone densitometry and ultrasonography of entheses), the digital X-rays and MRI of the spine and pelvis are stored using a specific software (Carestream) and the biological samples (DNA, RNA, sera, urines) are centralized at the Biological Resources Center (Bichat Hospital).

RESULTS

The recruitment period of the 708 patients (mean age: 34±9years, female 54%, HLA-B27 positive: 57%) in the 25 centers was 26 months (from December 2007 to April 2010). The modified New York criteria, Amor criteria, ESSG criteria and axial ASAS criteria were fulfilled by 26%, 77%, 76% and 67% of the patients at entry, respectively. A history or current symptoms suggestive of peripheral arthritis, acute anterior uveitis and inflammatory bowel disease were observed in 21%, 9% and 4% of the patients, respectively. The disease was active (BASDAI: 45±20) despite an NSAID intake in 66% of the patients.

CONCLUSION

This large cohort should facilitate the conduct of researches in different areas (clinical, medico-economics, translational) in order to improve our knowledge on the pathogenesis and natural history of axial spondyloarthritis.

摘要

目的

为了建立数据库，以促进早期炎症性背痛和脊柱关节炎领域的诊断、预后、流行病学、发病机制和医学经济学等方面的多项研究，法国风湿病学会启动了一项针对早期炎症性背痛患者的大型全国多中心、纵向、前瞻性随访研究。

方法

如果患者有超过 3 个月但少于 3 年的炎症性背痛，则招募患者。在最初的 2 年内，患者将每 6 个月随访一次，然后至少在 5 年内每年随访一次。除了在病例报告表上收集信息（人口统计学、疾病活动度、严重程度、合并症、社会经济学、治疗方法、脊柱和骨盆的放射学和 MRI 评估（根据当地研究人员），以及对于一些中心，骨密度和肌腱附着处的超声检查）外，脊柱和骨盆的数字 X 射线和 MRI 使用特定软件（Carestream）存储，生物样本（DNA、RNA、血清、尿液）集中在生物资源中心（Bichat 医院）。

结果

25 个中心的 708 名患者（平均年龄：34±9 岁，女性 54%，HLA-B27 阳性：57%）的招募期为 26 个月（2007 年 12 月至 2010 年 4 月）。在入组时，分别有 26%、77%、76%和 67%的患者符合改良纽约标准、阿莫尔标准、ESSG 标准和轴性 ASAS 标准。分别有 21%、9%和 4%的患者有外周关节炎、急性前葡萄膜炎和炎症性肠病的既往或当前症状。尽管 66%的患者服用了 NSAID，但仍有 66%的患者 BASDAI 为 45±20。