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2009 年甲型 H1N1 疫苗在低收入儿童和青少年人群中的覆盖及时性。

Timeliness of 2009 H1N1 vaccine coverage in a low-income pediatric and adolescent population.

机构信息

Division of General Pediatrics, Columbia University, New York, NY, United States.

出版信息

Vaccine. 2013 Apr 12;31(16):2103-7. doi: 10.1016/j.vaccine.2011.03.062. Epub 2011 Mar 31.

Abstract

Despite being at highest risk for 2009 H1N1 virus morbidity and mortality, many children were not immunized with the vaccine. Identification of factors that put certain children at higher risk for under-immunization could reveal populations who may need to be specifically targeted for vaccination interventions in future pandemics. Little is known about the prevalence of, or factors associated with, 2009 H1N1 vaccine coverage in low-income, urban pediatric populations. This study evaluated 2009 H1N1 vaccination coverage in 19,643 children aged 6months to 18years receiving care at one of five community clinics associated with an academic medical center in a low-income community. Any (≥1 dose) and full coverage (1 dose for children ≥10years old, 2 doses for those <10years) was determined as of December 1, 2009 and the end of vaccination period (June 30, 2010). Multivariable analyses were used to assess the impact of race/ethnicity, age, insurance, gender, and language on vaccine coverage and timeliness. By December 1, only 16.6% of children had received one dose, and 5.3% had full coverage. By the end of the vaccination period, 36.2% had received at least one H1N1 dose and 23.6% had full coverage. On multivariable analysis, older age, minority race/ethnicity, and private insurance were negatively associated with vaccination by December 1 and end of vaccination period, even after accounting for attendance at a clinic visit. In future pandemics, when timely receipt of a new vaccine in large populations may be imperative, general vaccination programs as well as special targeted education and vaccine reminders for these at risk groups may be warranted.

摘要

尽管儿童患 2009 年 H1N1 病毒的发病率和死亡率最高,但许多儿童并未接种疫苗。确定使某些儿童更易出现免疫不足的因素,可以揭示出在未来大流行中可能需要特别针对特定人群进行疫苗接种干预的人群。在低收入城市儿科人群中,对 2009 年 H1N1 疫苗接种覆盖率的了解甚少,也不了解与该覆盖率相关的因素。本研究评估了在一家学术医疗中心附属的五家社区诊所中接受治疗的 19643 名 6 个月至 18 岁儿童中 2009 年 H1N1 疫苗的接种覆盖率。截至 2009 年 12 月 1 日和接种期结束(2010 年 6 月 30 日),确定了任何剂量(≥1 剂)和完全覆盖(≥10 岁儿童 1 剂,<10 岁儿童 2 剂)。采用多变量分析评估种族/民族、年龄、保险、性别和语言对疫苗接种覆盖率和及时性的影响。截至 12 月 1 日,只有 16.6%的儿童接受了一剂,5.3%的儿童完全接种了疫苗。在接种期结束时,36.2%的儿童至少接种了一剂 H1N1 疫苗,23.6%的儿童完全接种了疫苗。在多变量分析中,即使在考虑到就诊次数后,年龄较大、少数族裔和私人保险与 12 月 1 日和接种期结束时的疫苗接种呈负相关。在未来的大流行中,当及时为大量人群提供新疫苗可能至关重要时,可能需要进行常规疫苗接种计划,以及针对这些高危人群的特别有针对性的教育和疫苗提醒。

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