绘制癌症起源图谱。
Mapping cancer origins.
机构信息
Department of Developmental Neurobiology and Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
出版信息
Cell. 2011 Apr 1;145(1):25-9. doi: 10.1016/j.cell.2011.03.019.
Abstract
Cancer comprises a bewildering assortment of diseases that kill 7.5 million people each year. Poor understanding of cancer's diversity currently thwarts our goal of a cure for every patient, but recent integration of genomic and stem cell technologies promises a route through this impasse.
摘要
癌症包括了一系列令人困惑的疾病，每年导致 750 万人死亡。目前，我们对癌症多样性的认识不足，阻碍了我们为每个患者治愈癌症的目标，但最近基因组学和干细胞技术的整合有望为我们提供一条走出困境的道路。
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1
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Nature. 2010 Dec 23;468(7327):1095-9. doi: 10.1038/nature09587. Epub 2010 Dec 8.
2
Medulloblastoma comprises four distinct molecular variants.
J Clin Oncol. 2011 Apr 10;29(11):1408-14. doi: 10.1200/JCO.2009.27.4324. Epub 2010 Sep 7.
3
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
Cell Stem Cell. 2010 Sep 3;7(3):403-17. doi: 10.1016/j.stem.2010.07.010.
4
Cross-species genomics matches driver mutations and cell compartments to model ependymoma.
Nature. 2010 Jul 29;466(7306):632-6. doi: 10.1038/nature09173. Epub 2010 Jul 18.
5
Progesterone induces adult mammary stem cell expansion.
Nature. 2010 Jun 10;465(7299):803-7. doi: 10.1038/nature09091.
6
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
Science. 2010 Mar 26;327(5973):1650-3. doi: 10.1126/science.1186624.
7
BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells.
Blood. 2010 Apr 22;115(16):3185-95. doi: 10.1182/blood-2009-04-215376. Epub 2010 Jan 6.
8
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.
Nat Med. 2009 Aug;15(8):907-13. doi: 10.1038/nm.2000. Epub 2009 Aug 2.
9
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.
Cell Stem Cell. 2008 Oct 9;3(4):429-41. doi: 10.1016/j.stem.2008.08.001.
10
Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
Nature. 2008 Oct 23;455(7216):1061-8. doi: 10.1038/nature07385. Epub 2008 Sep 4.
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