Department of Preclinical Sciences, Faculty of Medicine, Universidad Católica del Maule, Talca 3460000, Chile.
Int J Environ Res Public Health. 2021 Sep 30;18(19):10309. doi: 10.3390/ijerph181910309.
Diethylstilbestrol (DES), a transplacental endocrine-disrupting chemical, was prescribed to pregnant women for several decades. The number of women who took DES is hard to know precisely, but it has been estimated that over 10 million people have been exposed around the world. DES was classified in the year 2000 as carcinogenic to humans. The deleterious effects induced by DES are very extensive, such as abnormalities or cancers of the genital tract and breast, neurodevelopmental alterations, problems associated with socio-sexual behavior, and immune, pancreatic and cardiovascular disorders. Not only pregnant women but also their children and grandchildren have been affected. Epigenetic alterations have been detected, and intergenerational effects have been observed. More cohort follow-up studies are needed to establish if DES effects are transgenerational. Even though DES is not currently in use, its effects are still present, and families previously exposed and their later generations deserve the continuity of the research studies.
己烯雌酚（DES）是一种具有胎盘内分泌干扰作用的化学物质，曾被开给孕妇使用数十年。服用 DES 的女性人数难以准确知晓，但据估计全世界有超过 1000 万人受到影响。DES 于 2000 年被归类为对人类具有致癌性。DES 引起的有害影响非常广泛，例如生殖道和乳房的异常或癌症、神经发育改变、与社会性行为相关的问题以及免疫、胰腺和心血管疾病。受影响的不仅是孕妇，还有她们的孩子和孙辈。已经检测到表观遗传改变，并观察到了代际效应。需要更多的队列随访研究来确定 DES 的影响是否具有跨代效应。尽管 DES 目前已不再使用，但它的影响仍然存在，曾受到暴露的家庭及其后代应该得到研究的延续。
