功能性 VEGFA-583C/T 变体对血管内皮生长因子水平和复发性自然流产风险的影响。
Effect of the functional VEGFA-583C/T variant on vascular endothelial growth factor levels and the risk of recurrent spontaneous miscarriage.
机构信息
Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
出版信息
Fertil Steril. 2011 Jun 30;95(8):2471-3. doi: 10.1016/j.fertnstert.2011.03.010. Epub 2011 Apr 2.
Abstract
The association of vascular endothelial growth factor (VEGF) -583C/T variant with recurrent miscarriage (RSM) was investigated in 173 RSM cases and 248 control women. Increased minor allele and genotype frequencies of -583C/T, and reduced serum VEGF concentrations were associated with increased risk of RSM.
摘要
研究人员调查了 173 例复发性流产（RSM）病例和 248 例对照女性的血管内皮生长因子（VEGF）-583C/T 变体的相关性。-583C/T 的次要等位基因和基因型频率增加，以及血清 VEGF 浓度降低与 RSM 风险增加相关。
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