Department of Obstetrics and Gynaecology, Shenzhen Baoan Women's and Children's Hospital, Shenzhen University, Shenzhen 518133, China.
Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Biomolecules. 2021 Feb 10;11(2):253. doi: 10.3390/biom11020253.
Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.
血管内皮生长因子（VEGF）是一种众所周知的血管生成因子，在各种生理和病理过程中起着关键作用。VEGF 还通过促进胚胎发育、改善子宫内膜容受性以及促进胚胎和子宫内膜之间的相互作用，参与胚胎着床过程。VEGF 表达的改变与生殖失败有关，包括反复着床失败（RIF）和反复自然流产（RM）。为了阐明 VEGF 在胚胎着床中的作用，我们回顾了最近关于 VEGF 在胚胎着床前后生殖系统中的表达和功能的文献，并对迄今为止报道的研究结果进行了总结。我们还探讨了 VEGF 在胚胎着床中的作用及其可能的作用机制。
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