Kolho Kaija-Leena, Heiskanen Kaarina, Verkasalo Matti, Pitkäranta Anne
Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Faculty of Medicine, Helsinki, Finland.
Int J Pediatr Otorhinolaryngol. 2011 Jun;75(6):864-7. doi: 10.1016/j.ijporl.2011.03.003. Epub 2011 Apr 1.
The data on orofacial granulomatosis, OFG, in children are sparse. We describe here 8 pediatric patients presenting with OFG, 2 of these cases associating with Crohn's disease. Therapeutic agents included systemic immunosuppressants such as glucocorticoids, methotrexate, anti-TNF-alpha agent, dapsone, antibiotics (metronidazole), and local treatment with topical tacrolimus or intralesional injections of triamcinolone hexacetonide. The treatment response ranged from good to poor results. The number of young patients suffering from OFG is not currently known and there are no gold standards for treatment. Thus, prospective follow-up studies on these patients are needed to gain more experience of the therapeutic responses.
关于儿童口腔面部肉芽肿病（OFG）的数据稀少。我们在此描述8例表现为OFG的儿科患者，其中2例与克罗恩病相关。治疗药物包括全身性免疫抑制剂，如糖皮质激素、甲氨蝶呤、抗TNF-α药物、氨苯砜、抗生素（甲硝唑），以及局部使用外用他克莫司或病灶内注射曲安奈德己酮。治疗反应从良好到不佳不等。目前尚不清楚患有OFG的年轻患者数量，且尚无治疗的金标准。因此，需要对这些患者进行前瞻性随访研究，以获得更多关于治疗反应的经验。
