Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.
Neurobiol Aging. 2012 Mar;33(3):619.e9-619.e24. doi: 10.1016/j.neurobiolaging.2011.02.005. Epub 2011 Apr 1.
Studies of recovery from stroke mainly utilize rodent models and focus primarily on young subjects despite the increased prevalence of stroke with age and the fact that recovery of function is more limited in the aged brain. In the present study, a nonhuman primate model of cortical ischemia was developed to allow the comparison of impairments in young and middle-aged monkeys. Animals were pretrained on a fine motor task of the hand and digits and then underwent a surgical procedure to map and lesion the hand-digit representation in the dominant motor cortex. Animals were retested until performance returned to preoperative levels. To assess the recovery of grasp patterns, performance was videotaped and rated using a scale adapted from human occupational therapy. Results demonstrated that the impaired hand recovers to baseline in young animals in 65-80 days and in middle-aged animals in 130-150 days. However, analysis of grasp patterns revealed that neither group recover preoperative finger thumb grasp patterns, rather they develop compensatory movements.
尽管随着年龄的增长中风的发病率增加，而且年龄较大的大脑的功能恢复更为有限，但中风后恢复的研究主要利用啮齿动物模型，并主要关注年轻的实验对象。在本研究中，建立了一种皮质局部缺血的非人类灵长类动物模型，以允许比较年轻和中年猴子的损伤。动物在手和手指的精细运动任务上进行了预训练，然后进行了手术，以在手运动皮层的优势代表区定位和损伤手-指代表区。对动物进行了重新测试，直到其表现恢复到术前水平。为了评估抓握模式的恢复情况，使用从人类职业治疗中改编的量表对性能进行了录像和评分。结果表明，在 65-80 天内，年轻动物的受损手恢复到基线水平，而在 130-150 天内，中年动物的受损手恢复到基线水平。但是，抓握模式的分析表明，两组都无法恢复术前的手指拇指抓握模式，而是发展出代偿运动。
