Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Parkinsonism Relat Disord. 2011 Jun;17(5):379-81. doi: 10.1016/j.parkreldis.2011.03.003. Epub 2011 Apr 2.
Impulse-control disorders (ICDs) are becoming more commonly recognized in the Parkinson disease (PD) population. To date, there are no definitive methods of treating dopamine dysregulation syndromes in PD patients. We sought to uncover an effective treatment option for future study. We report a series of 3 PD patients with ICDs who were effectively treated with valproate. Based on these encouraging preliminary observations, future controlled clinical trials investigating the efficacy of valproate for ICDs in PD are recommended.
冲动控制障碍（ICD）在帕金森病（PD）患者中越来越常见。迄今为止，尚无明确的方法可治疗 PD 患者的多巴胺失调综合征。我们试图为未来的研究发现一种有效的治疗选择。我们报告了一系列 3 例使用丙戊酸钠有效治疗 ICD 的 PD 患者。基于这些令人鼓舞的初步观察结果，建议未来进行对照临床试验，以研究丙戊酸钠对 PD 中 ICD 的疗效。
