Leeman Robert F, Billingsley Benjamin E, Potenza Marc N
Department of Psychiatry, Yale University School of Medicine, CMHC, Room S200, 34 Park Street, New Haven, CT 06519, USA.
Neurodegener Dis Manag. 2012 Aug 1;2(4):389-400. doi: 10.2217/nmt.12.35.
Given that impulse control disorders (ICDs) have been identified among a considerable minority of Parkinson's disease (PD) patients, these conditions have gained increased clinical and research attention in the past decade. Dopamine-replacement therapies, taken to ameliorate PD symptoms, have been associated with ICDs in PD. Unfortunately, there are relatively sparse empirical data regarding how best to address ICDs in PD patients. Conversely, progress has been made in understanding the clinical, neurobiological and cognitive correlates of ICDs in PD. Some of these findings may inform possible courses of action for care providers working with PD patients with ICDs. The literature on ICDs in non-PD populations may also be informative in this regard. The goals of the present article are to outline important clinical characteristics of ICDs in PD, briefly review relevant neurocognitive and neurobiological studies and discuss possible ways to prevent and manage ICDs in PD.
鉴于相当一部分帕金森病（PD）患者已被发现存在冲动控制障碍（ICD），在过去十年中，这些病症在临床和研究方面受到了更多关注。用于改善PD症状的多巴胺替代疗法与PD患者的ICD有关。不幸的是，关于如何最好地处理PD患者的ICD的实证数据相对较少。相反，在理解PD中ICD的临床、神经生物学和认知相关性方面已经取得了进展。其中一些发现可能为治疗患有ICD的PD患者的医护人员提供可能的行动方案。关于非PD人群中ICD的文献在这方面也可能具有参考价值。本文的目的是概述PD中ICD的重要临床特征，简要回顾相关的神经认知和神经生物学研究，并讨论预防和管理PD中ICD的可能方法。
