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药物基因组学检测：医学实践中的相关性：为什么有些患者的药物有效而有些患者的药物无效。

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.

机构信息

Department of Pharmacology, Division of Clinical Trials, College of Medicine, The Ohio State University, Columbus, USA.

出版信息

Cleve Clin J Med. 2011 Apr;78(4):243-57. doi: 10.3949/ccjm.78a.10145.

DOI:10.3949/ccjm.78a.10145
PMID:21460130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3351041/
Abstract

Genetics may account for much of the variability in our patients' responses to drug therapies. This article offers the clinician an up-to-date overview of pharmacogenomic testing, discussing implications and limitations of emerging validated tests relevant to the use of warfarin (Coumadin), clopidogrel (Plavix), statins, tamoxifen (Nolvadex), codeine, and psychotropic drugs. It also discusses the future role of pharmacogenomic testing in medicine.

摘要

遗传学可能解释了我们的患者对药物治疗反应存在差异的很大一部分原因。本文为临床医生提供了关于药物基因组学检测的最新概述，讨论了与华法林（Coumadin）、氯吡格雷（Plavix）、他汀类药物、他莫昔芬（Nolvadex）、可待因和精神药物使用相关的新兴经过验证的检测的意义和局限性。本文还讨论了药物基因组学检测在医学中的未来作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c291/3351041/80396737233b/nihms372885f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c291/3351041/0b992fa3e317/nihms372885f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c291/3351041/80396737233b/nihms372885f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c291/3351041/0b992fa3e317/nihms372885f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c291/3351041/80396737233b/nihms372885f2.jpg

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本文引用的文献

1
Effects of CYP2C19 genotype on outcomes of clopidogrel treatment.CYP2C19 基因型对氯吡格雷治疗结局的影响。
N Engl J Med. 2010 Oct 28;363(18):1704-14. doi: 10.1056/NEJMoa1008410. Epub 2010 Aug 29.
2
ACCF/AHA Clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association.美国心脏病学会基金会/美国心脏协会氯吡格雷临床警报：应对美国食品药品监督管理局“黑框警告”：美国心脏病学会基金会临床专家共识文件特别工作组和美国心脏协会的报告
Circulation. 2010 Aug 3;122(5):537-57. doi: 10.1161/CIR.0b013e3181ee08ed. Epub 2010 Jun 28.
3
Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs.CYP3A4 内含子多态性影响肝表达和对他汀类药物的反应。
Pharmacogenomics J. 2011 Aug;11(4):274-86. doi: 10.1038/tpj.2010.28. Epub 2010 Apr 13.
4
Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study).华法林基因分型降低了住院率，这是 MM-WES（美科梅奥华法林有效性研究）的结果。
J Am Coll Cardiol. 2010 Jun 22;55(25):2804-12. doi: 10.1016/j.jacc.2010.03.009. Epub 2010 Apr 8.
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Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility.全基因组范围内测量顺式作用调控变体：对表达遗传学和疾病易感性的新见解。
Genome Med. 2009 Dec 22;1(12):116. doi: 10.1186/gm116.
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Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.复合功能遗传和共用药 CYP2D6 活性评分预测乳腺癌患者他莫昔芬药物暴露。
J Clin Pharmacol. 2010 Apr;50(4):450-8. doi: 10.1177/0091270009359182. Epub 2010 Jan 15.
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Pharmacogenomics J. 2010 Feb;10(1):1-11. doi: 10.1038/tpj.2009.54. Epub 2009 Nov 3.
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Clin Pharmacol Ther. 2009 Dec;86(6):634-43. doi: 10.1038/clpt.2009.151. Epub 2009 Aug 26.