Takahashi Kayo, Onoe Kayo, Doi Hisashi, Nagata Hiroko, Yamagishi Gen, Hosoya Takamitsu, Tamura Yasuhisa, Wada Yasuhiro, Yamanaka Hajime, Yokoyama Chihiro, Mizuma Hiroshi, Takashima Tadayuki, Bergström Mats, Onoe Hirotaka, Långström Bengt, Watanabe Yasuyoshi
RIKEN Center for Molecular Imaging Science, Chuo-ku, Kobe, Hyogo, Japan.
Neuroreport. 2011 May 11;22(7):326-30. doi: 10.1097/WNR.0b013e3283460282.
In an earlier study in rodents, we showed that the aromatase that converts androgens to estrogens in the preoptic area and bed nucleus of stria terminalis was significantly increased in concentration after exposure to anabolic-androgenic steroids. To confirm whether this occurs in primates, we conducted a positron emission tomographic study using macaque monkeys. Male rhesus monkeys were treated with nandrolone decanoate for 3 weeks. To measure aromatase concentrations, we performed positron emission tomographic imaging using a 11C-labeled specific aromatase inhibitor, [11C]vorozole. After treatment with nandrolone, significant increase in [11C]vorozole binding was observed in the hypothalamus but not other areas including the amygdala, which is also aromatase enriched. These findings in monkeys are consistent with those we obtained earlier in rats. These findings strongly suggest that aromatase in the hypothalamus may play a crucial role in the emotional instability of anabolic-androgenic steroids abusers.
在一项早期针对啮齿动物的研究中，我们发现，在接触合成代谢雄性激素类固醇后，视前区和终纹床核中负责将雄激素转化为雌激素的芳香化酶浓度显著增加。为了确认这种情况是否也发生在灵长类动物中，我们使用猕猴进行了一项正电子发射断层扫描研究。雄性恒河猴接受了3周的癸酸诺龙治疗。为了测量芳香化酶浓度，我们使用一种11C标记的特异性芳香化酶抑制剂[11C]伏洛唑进行了正电子发射断层扫描成像。在用诺龙治疗后，在下丘脑观察到[11C]伏洛唑结合显著增加，但在包括杏仁核（其也富含芳香化酶）在内的其他区域未观察到这种增加。猴子的这些发现与我们早期在大鼠中获得的结果一致。这些发现强烈表明，下丘脑的芳香化酶可能在合成代谢雄性激素类固醇滥用者的情绪不稳定中起关键作用。
