Mirzaei K, Hossein-Nezhad A, Chamari M, Shahbazi S
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Minerva Endocrinol. 2011 Mar;36(1):13-21.
ANGPTL6 (Angiopoietin-related growth factor 6) is a circulating protein which is suggested to antagonize obesity. The purpose of this study was to evaluate a potential relationship between fasting serum ANGPTL6 and resting metabolic rate (RMR) as well as the body composition in obese and subjects with normal weight.
Participants were 62 obese and 41 non-obese subjects who were assessed following an overnight fasting for RMR by means of indirect calorimetry. Body composition was measured using Bodystat devise. Serum ANGPTL6 levels were quantified by ELISA method.
Based on ROC analysis best RMR/kg cut-off value for predicting the risk of obesity was 20 kcal/24h /kg. The participants with RMR/kg≥20 kcal/24h/kg were considered as and subjects with RMR/kg<20 kcal/24h/kg were categorized as. In group I, 72.3% of subjects were obese, whereas, 47.4% subjects in group II were suffering from the disease. Participants in group II who showed significantly lower HDL and ANGPTL6 levels. Moreover, we found significantly higher triglyceride and hs-CRP levels in this group. There was significant difference in weight, body mass index, fat mass, visceral fat, RMR/kg, fasting serum glucose, insulin and hs-CRP among those with different levels of the serum ANGPTL6 concentration. We found higher values of RMR/kg in subjects with higher circulating ANGPTL6 concentration.
ANGPTL6 affects RMR and significantly improves lipid profile and slightly does so regarding insulin concentrations and sensitivity to it. Further study is warranted as it seems that the results of this study might potentially lead to advent of a pharmacological treatment for obesity.
血管生成素相关生长因子6（ANGPTL6）是一种循环蛋白，被认为可对抗肥胖。本研究旨在评估肥胖和体重正常受试者空腹血清ANGPTL6与静息代谢率（RMR）以及身体成分之间的潜在关系。
62名肥胖受试者和41名非肥胖受试者参与研究，他们在过夜禁食后通过间接量热法评估RMR。使用Bodystat设备测量身体成分。采用酶联免疫吸附测定（ELISA）法对血清ANGPTL6水平进行定量分析。
基于受试者工作特征（ROC）分析，预测肥胖风险的最佳RMR/体重截断值为20千卡/24小时/千克。RMR/体重≥20千卡/24小时/千克的参与者被视为……，而RMR/体重<20千卡/24小时/千克的参与者被归类为……。在第一组中，72.3%的受试者肥胖，而在第二组中，47.4%的受试者患有该疾病。第二组参与者的高密度脂蛋白（HDL）和ANGPTL6水平显著较低。此外，我们发现该组的甘油三酯和超敏C反应蛋白（hs-CRP）水平显著较高。血清ANGPTL6浓度不同的受试者在体重、体重指数、脂肪量、内脏脂肪、RMR/体重、空腹血清葡萄糖、胰岛素和hs-CRP方面存在显著差异。我们发现循环ANGPTL6浓度较高的受试者的RMR/体重值更高。
ANGPTL6影响RMR，并显著改善血脂谱，对胰岛素浓度及其敏感性也有轻微改善。鉴于本研究结果可能会带来肥胖药物治疗方法，因此有必要进行进一步研究。
