Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Gut Liver. 2011 Mar;5(1):100-4. doi: 10.5009/gnl.2011.5.1.100. Epub 2011 Mar 16.
Cutaneous metastases from internal malignancies are uncommon. Furthermore, cutaneous metastases from cholangiocarcinoma are extremely rare. Here we report a case of two patients with distant cutaneous metastases of cholangiocarcinoma: 1) a 66-year-old man who presented with a solitary, erythematous nodule on the scalp and 2) a 44-year-old man who presented with multiple, erythematous nodules on the scalp, the chest wall, and the back. In both cases, the erythematous nodules were the first clinical signs of cholangiocarcinoma. Histopathological analyses of skin biopsy specimens of the two patients revealed adenocarcinomas with features similar to the original cholangiocarcinoma. Two cases of cholangiocarcinoma in which metastatic skin nodules appeared as the first sign of the disease are reported here, with a review of the relevant literature.
皮肤转移来自于内部恶性肿瘤并不常见。此外，胆管癌的皮肤转移极其罕见。在此我们报告两例胆管癌远处皮肤转移的病例：1）一名 66 岁男性，头皮单发红斑性结节；2）一名 44 岁男性，头皮、胸壁和背部多发性红斑性结节。在这两例患者中，红斑性结节均为胆管癌的首发临床征象。对两名患者皮肤活检标本的组织病理学分析显示，腺癌具有与原始胆管癌相似的特征。现报告两例胆管癌中，转移性皮肤结节作为疾病的首发征象，同时对相关文献进行了复习。
