Kyung Sun Young, Cho Yong Kyun, Kim Yu Jin, Park Jeong-Woong, Jeong Sung Hwan, Lee Jae-Ik, Sung Yon Mi, Lee Sang Pyo
Department of Medicine, Gachon University Gil Medical Center, Incheon 405-760, Korea.
Korean J Parasitol. 2011 Mar;49(1):73-7. doi: 10.3347/kjp.2011.49.1.73. Epub 2011 Mar 18.
Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.
肺吸虫病是一种由肺吸虫属吸虫引起的传染病。在超过90%的病例中，这种吸虫可用吡喹酮成功治疗。尽管吡喹酮一般耐受性良好，但少数病例报告了对该药物的过敏反应。我们在此报告一名46岁的韩国女性肺吸虫病患者，推测由卫氏并殖吸虫引起，该患者对吡喹酮表现出过敏反应且对三氯苯达唑治疗耐药。该患者在快速脱敏程序后用吡喹酮成功治疗。当没有其他替代药物可用时，可以考虑对吡喹酮进行脱敏治疗。
