Vasconcelos Géssica Almeida, Costa Bernardo Gratival Gouvea, Dos Santos Ronald Alves, de Faria Carolina Dourado, Schramm Neto Fernando Antônio Ramos, Machado Yuri de Jesus, Casaes Ane Caroline, de Oliveira Marcos Vinicius Lima, Fialho Thainá Rodrigues de Souza, Dos Santos Keila Ramos, Oliveira Bruna Souza S, Oliveira Ricardo Riccio, de Siqueira Isadora Cristina
Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, Brazil.
IJID Reg. 2023 Apr 15;7:268-270. doi: 10.1016/j.ijregi.2023.04.007. eCollection 2023 Jun.
Praziquantel (PZQ) is a medication used to treat several parasitic infections, including human schistosomiasis. Although this drug commonly causes transient adverse effects, severe hypersensitivity is rare, and only eight cases have been reported worldwide. Herein we report a case of a 13-year-old Brazilian female who developed anaphylaxis, a severe hypersensitive reaction, after taking praziquantel to treat infection During a mass drug administration event in a socially vulnerable endemic area of Bahia (Brazil), after taking 60 mg/kg of praziquantel the patient developed rash and generalized edema an hour later, evolving to somnolence and hypotension. Following the anaphylactic episode, she received adequate treatment and recovered approximately 1 day later. Although praziquantel is considered safe, health professionals should be aware of potential life-threatening adverse events.
吡喹酮（PZQ）是一种用于治疗多种寄生虫感染的药物，包括人类血吸虫病。虽然这种药物通常会引起短暂的不良反应，但严重过敏反应很少见，全球仅报告了8例。在此，我们报告一例13岁巴西女性病例，该患者在巴西巴伊亚州一个社会弱势群体流行地区进行大规模药物给药活动期间，服用吡喹酮治疗感染后发生了过敏反应，这是一种严重的过敏反应。服用60mg/kg吡喹酮一小时后，患者出现皮疹和全身性水肿，随后发展为嗜睡和低血压。过敏反应发生后，她接受了适当治疗，大约1天后康复。虽然吡喹酮被认为是安全的，但卫生专业人员应意识到潜在的危及生命的不良事件。
