Riccio Paolo, Rossano Rocco, Liuzzi Grazia Maria
Dipartimento di Biologia D.B.A.F., Università degli Studi della Basilicata, 85100 Potenza, Italy.
Autoimmune Dis. 2011 Feb 24;2010:249842. doi: 10.4061/2010/249842.
Multiple sclerosis is a complex and multifactorial neurological disease, and nutrition is one of the environmental factors possibly involved in its pathogenesis. At present, the role of nutrition is unclear, and MS therapy is not associated to a particular diet. MS clinical trials based on specific diets or dietary supplements are very few and in some cases controversial. To understand how diet can influence the course of MS and improve the wellness of MS patients, it is necessary to identify the dietary molecules, their targets and the molecular mechanisms involved in the control of the disease. The aim of this paper is to provide a molecular basis for the nutritional intervention in MS by evaluating at molecular level the effect of dietary molecules on the inflammatory and autoimmune processes involved in the disease.
多发性硬化症是一种复杂的多因素神经疾病，营养是可能涉及其发病机制的环境因素之一。目前，营养的作用尚不清楚，且多发性硬化症的治疗与特定饮食无关。基于特定饮食或膳食补充剂的多发性硬化症临床试验非常少，而且在某些情况下存在争议。为了了解饮食如何影响多发性硬化症的病程并改善患者的健康状况，有必要确定饮食分子、它们的靶点以及参与疾病控制的分子机制。本文的目的是通过在分子水平评估饮食分子对该疾病所涉及的炎症和自身免疫过程的影响，为多发性硬化症的营养干预提供分子基础。
