Sandhu Sukhinder K, Croce Carlo M, Garzon Ramiro
Department of Molecular Virology, Immunology and Medical Genetics, Molecular and Cellular Developmental Biology Program, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Adv Hematol. 2011;2011:347137. doi: 10.1155/2011/347137. Epub 2011 Mar 22.
The recent discovery of microRNAs (miRNAs) has introduced a new layer of complexity to the process of gene regulation. MiRNAs are essential for cellular function, and their dysregulation often results in disease. Study of miRNA expression and function in animal models and human lymphomas has improved our knowledge of the pathogenesis of this heterogeneous disease. In this paper, we attempt to describe the expression of miRNAs and their function in lymphomas and discuss potential miRNA-based therapies in the diagnosis and treatment of lymphomas.
微小RNA（miRNA）的最新发现为基因调控过程引入了一层新的复杂性。miRNA对细胞功能至关重要，其失调常常导致疾病。对动物模型和人类淋巴瘤中miRNA表达及功能的研究增进了我们对这种异质性疾病发病机制的了解。在本文中，我们试图描述miRNA在淋巴瘤中的表达及其功能，并讨论基于miRNA的疗法在淋巴瘤诊断和治疗中的潜力。
