Shin Jonghan, Tsui Wai, Li Yi, Lee Sang-Yoon, Kim Seog Ju, Cho Seong-Jin, Kim Young-Bo, de Leon Mony J
Neuroscience Research Institute and Department of Psychiatry, Gachon University of Medicine and Science, Incheon 405-760, Republic of Korea.
Int J Alzheimers Dis. 2011 Mar 17;2011:759780. doi: 10.4061/2011/759780.
It has been suggested that glucose metabolism within the brain's default network is directly associated with-and may even cause-the amyloid pathology of Alzheimer's disease (AD). Here we performed 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) and [(11)C]-labeled Pittsburgh Compound B (PIB) positron emission tomography (PET) on cognitively normal elderly subjects and on AD patients and conducted quantitative regional analysis of FDG- and PIB-PET images using an automated region of interest technique. We confirmed that resting glucose metabolism within the posterior components of the brain's default network is high in normal elderly subjects and low in AD patients, which is partially in agreement with the regional pattern of PIB uptake within the default network of AD patients. However, in several regions outside the default network, glucose metabolism was high in normal elderly subjects but was not depressed in AD patients, who exhibited significantly increased PIB uptakes in these regions. In contrast, the level of resting glucose metabolism in the default network and in regions outside the default network in normal elderly subjects was significantly correlated with the level of regional PIB uptake in AD patients. These results are discussed with experimental evidence suggesting that beta amyloid production and amyloid precursor protein regulation are dependent on neuronal activity.
有人提出，大脑默认网络内的葡萄糖代谢与阿尔茨海默病（AD）的淀粉样蛋白病理直接相关，甚至可能导致该病理。在此，我们对认知正常的老年受试者和AD患者进行了2-[(18)F]氟-2-脱氧-D-葡萄糖（FDG）和[(11)C]标记的匹兹堡化合物B（PIB）正电子发射断层扫描（PET），并使用自动感兴趣区域技术对FDG和PIB-PET图像进行了定量区域分析。我们证实，大脑默认网络后部组件内的静息葡萄糖代谢在正常老年受试者中较高，而在AD患者中较低，这与AD患者默认网络内PIB摄取的区域模式部分一致。然而，在默认网络之外的几个区域，正常老年受试者的葡萄糖代谢较高，但AD患者的葡萄糖代谢并未降低，这些患者在这些区域的PIB摄取显著增加。相反，正常老年受试者默认网络内和默认网络之外区域的静息葡萄糖代谢水平与AD患者区域PIB摄取水平显著相关。我们结合实验证据对这些结果进行了讨论，这些证据表明β淀粉样蛋白的产生和淀粉样前体蛋白的调节依赖于神经元活动。
