Shin Jonghan, Kepe Vladimir, Small Gary W, Phelps Michael E, Barrio Jorge R
Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon 405-760, Republic of Korea.
Int J Alzheimers Dis. 2011;2011:687945. doi: 10.4061/2011/687945. Epub 2011 Apr 19.
The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention. In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN. Multitracer PET imaging in subjects with and without dementia has demonstrated that [C-11]PIB- and [F-18]FDDNP-binding patterns in patients with AD overlap within nodes of the brain's default network including the prefrontal, lateral parietal, lateral temporal, and posterior cingulate cortices, with the exception of the medial temporal cortex (especially, the hippocampus) where significant discrepancy between increased [F-18]FDDNP binding and negligible [C-11]PIB-binding was observed. [F-18]FDDNP binding in the medial temporal cortex-a key constituent of the DMN-coincides with both the presence of amyloid and tau pathology, and also with cortical areas with maximal atrophy as demonstrated by T1-weighted MR imaging of AD patients.
大脑默认模式网络（DMN）与已知在阿尔茨海默病（AD）中发生病理生理变化的脑区之间的空间相关性最近备受关注。在本文中，我们比较了不同功能和结构成像模态的结果，包括MRI和PET，并突出了在DMN中观察到的不同异常模式。对患有和未患痴呆症的受试者进行的多示踪剂PET成像表明，AD患者中[C-11]PIB和[F-18]FDDNP的结合模式在大脑默认网络的节点内重叠，这些节点包括前额叶、外侧顶叶、外侧颞叶和后扣带回皮质，但内侧颞叶皮质（特别是海马体）除外，在该区域观察到[F-18]FDDNP结合增加与[C-11]PIB结合可忽略不计之间存在显著差异。内侧颞叶皮质（DMN的关键组成部分）中的[F-18]FDDNP结合与淀粉样蛋白和tau病理的存在以及AD患者T1加权MRI成像显示的最大萎缩皮质区域均相符。
