Department of Gastroenterology, Yamagata University, Japan.
Ann Nucl Med. 2011 Aug;25(7):520-3. doi: 10.1007/s12149-011-0484-0. Epub 2011 Apr 2.
We describe a 62-year-old woman with advanced chronic hepatitis C who showed no response to low-dose long-term interferon-beta monotherapy (3 MU, three times a week). The interferon monotherapy was continued for 2 years and 9 months. Despite this lack of response to interferon, the patient's clinical course was good and liver function assessed by (99m)Tc-galactosyl human serum albumin single photon emission computed tomography ((99m)Tc-GSA SPECT) analysis improved significantly. Improvement of the data obtained by (99m)Tc-GSA SPECT analysis justified continuation of the treatment. (99m)Tc-GSA SPECT analysis was clinically useful to evaluate the effect of interferon in a patient with interferon non-responsive chronic hepatitis C, despite a lack of reduction of the ALT level and HCV-RNA titer.
我们描述了一位 62 岁的女性慢性丙型肝炎患者，她对低剂量长期干扰素-β单药治疗（3MU，每周三次）没有反应。干扰素单药治疗持续了 2 年零 9 个月。尽管干扰素治疗没有反应，但患者的临床过程良好，(99m)Tc-半乳糖基人血清白蛋白单光子发射计算机断层扫描((99m)Tc-GSA SPECT)分析评估的肝功能显著改善。(99m)Tc-GSA SPECT 分析数据的改善证明了继续治疗的合理性。尽管 ALT 水平和 HCV-RNA 载量没有降低，但(99m)Tc-GSA SPECT 分析对评估干扰素治疗无反应的慢性丙型肝炎患者的疗效具有临床意义。
