Kira T, Tomiguchi S, Takahashi M, Yoshimatsu S, Sagara K, Kurano R
Department of Radiology, Kumamoto University School of Medicine, Japan.
Radiat Med. 1999 Mar-Apr;17(2):125-30.
99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) liver scintigraphy was performed in 230 patients with chronic active hepatitis type C, and its quantitative indices were compared with histological findings. 99mTc-GSA findings correlated well with four indices of the histology activity index (HAI), especially with the fibrosis score. Ninety patients were given interferon treatments, and 99mTc-GSA findings were compared with the results of the treatments. We classified the effects of interferon treatment into three groups according to clinical outcome: group 1: good effect (HCV-RNA negative, n = 34), group 2: moderate effect (HCV-RNA positive, but the value of GPT was normal for six months after the end of treatment, n = 19) and group 3: no effect (n = 37). Quantitative indices of 99mTc-GSA showed significant differences between groups. Follow-up study with 99mTc-GSA scintigrams was obtained in eight patients. The results of 99mTc-GSA improved in three patients in group 1 and deteriorated in five patients in group 3. There is a possibility that 99mTc-GSA scintigraphy can be used to predict the clinical outcome of chronic active hepatitis type C after interferon treatment.
对230例丙型慢性活动性肝炎患者进行了99m锝-二乙三胺五乙酸-半乳糖基人血清白蛋白（99mTc-GSA）肝脏闪烁扫描，并将其定量指标与组织学检查结果进行比较。99mTc-GSA检查结果与组织学活动指数（HAI）的四个指标密切相关，尤其是与纤维化评分。90例患者接受了干扰素治疗，并将99mTc-GSA检查结果与治疗结果进行比较。根据临床结果，我们将干扰素治疗的效果分为三组：第1组：效果良好（HCV-RNA阴性，n = 34），第2组：效果中等（HCV-RNA阳性，但治疗结束后6个月GPT值正常，n = 19），第3组：无效果（n = 37）。99mTc-GSA的定量指标在各组之间存在显著差异。对8例患者进行了99mTc-GSA闪烁扫描的随访研究。第1组中有3例患者的99mTc-GSA结果有所改善，第3组中有5例患者的结果恶化。99mTc-GSA闪烁扫描有可能用于预测干扰素治疗后丙型慢性活动性肝炎的临床结果。
