Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Vet Res Commun. 2011 Jun;35(5):271-82. doi: 10.1007/s11259-011-9471-0. Epub 2011 Apr 2.
This research aimed to determine the value of esophageal pH in awake and anesthetized dogs, to evaluate the esophageal pH value in awake dogs, in different body positions, as well as to study the occurrence of gastroesophageal reflux episodes in these positions. Thus, 40 healthy male and female adult dogs with mean body weight of 15.5 ± 4.6 kg were used. Esophageal pHmetry was conducted by inserting a catheter through the oropharynx in 30 dogs (stage 1) anesthetized with acepromazine, propofol and isoflurane, submitted to elective ovariosalpingohysterectomy. In addition, 8-h esophageal pHmetry was carried out transnasally in 10 awake dogs (stage 2), allowed to move and change body positions (lateral and sternal decubitus, and standing position), which were recorded. The mean esophageal pH value was lower (p < 0.01) in the anesthetized dogs (7.3 ± 0.82) than in the awake dogs (8.2 ± 0.3). Only four anesthetized dogs (13.33%) suffered reflux episodes. Reflux was not observed in the awake dogs and no esophageal pH differences were found between the body positions studied. Compared to the alert state, general anesthesia in dogs submitted to the previously mentioned anesthesia protocol causes esophageal pH reduction and predisposes to the occurrence of gastroesophageal reflux episodes. Transnasal pHmetry of 8 h in healthy awake dogs reveals that the esophageal pH value is alkaline and does not vary according to body position. In these animals, decubitus position is not a determining factor for reflux episodes to occur.
本研究旨在确定清醒和麻醉犬食管 pH 值的价值,评估清醒犬在不同体位下的食管 pH 值,以及研究这些体位下胃食管反流事件的发生情况。因此,使用了 40 只平均体重为 15.5±4.6kg 的健康雄性和雌性成年犬。在 30 只犬(第 1 阶段)中通过口咽部插入导管进行食管 pH 测量,这些犬用乙酰丙嗪、异丙酚和异氟烷麻醉,进行择期卵巢子宫切除术。此外,10 只清醒犬(第 2 阶段)进行了 8 小时的经鼻食管 pH 测量,允许它们移动和改变体位(侧卧和仰卧位,以及站立位),并进行记录。麻醉犬的平均食管 pH 值较低(p<0.01)(7.3±0.82),而清醒犬的平均食管 pH 值较高(8.2±0.3)。只有 4 只麻醉犬(13.33%)发生反流事件。在清醒犬中未观察到反流,且研究的体位之间未发现食管 pH 值差异。与警觉状态相比,在接受上述麻醉方案的犬中进行全身麻醉会导致食管 pH 值降低,并易发生胃食管反流事件。8 小时的健康清醒犬经鼻 pH 测量显示,食管 pH 值呈碱性,且不随体位变化而变化。在这些动物中,卧位不是反流事件发生的决定因素。