Medical Science and Human Medicine Study Programme, Karl Landsteiner University of Health Sciences, 3500 Krems an der Donau, Austria.
Department of Physical Medicine and Rehabilitation, Medical University of Vienna, 1090 Vienna, Austria.
Int J Mol Sci. 2022 Feb 28;23(5):2701. doi: 10.3390/ijms23052701.
Age-related chronic diseases are an enormous burden to modern societies worldwide. Among these, osteoporosis, a condition that predisposes individuals to an increased risk of fractures, substantially contributes to increased mortality and health-care costs in elderly. It is now well accepted that advanced chronical age is one of the main risk factors for chronical diseases. Hence, targeting fundamental aging mechanisms such as senescence has become a promising option in the treatment of these diseases. Moreover, for osteoporosis, the main pathophysiological concepts arise from menopause causing estrogen deficiency, and from aging. Here, we focus on recent advances in the understanding of senescence-related mechanisms contributing to age-related bone loss. Furthermore, treatment options for senile osteoporosis targeting senescent cells are reviewed.
与年龄相关的慢性疾病是全球现代社会的沉重负担。在这些疾病中，骨质疏松症使个体易骨折的风险增加，这大大增加了老年人的死亡率和医疗保健成本。现在人们普遍认为，高龄是慢性疾病的主要危险因素之一。因此，针对衰老等基本衰老机制已成为治疗这些疾病的一种有前途的选择。此外，对于骨质疏松症，主要的病理生理概念源于绝经引起的雌激素缺乏和衰老。在这里，我们专注于理解与年龄相关的骨丢失相关的衰老相关机制的最新进展。此外，还回顾了针对衰老细胞的治疗老年性骨质疏松症的治疗选择。
