Jiang Zhi-Yong, Bai Xi-Shan, Liang Hui, Wang Chao, Li Wen-Juan, Guo Jun-Ming, Huang Xiang-Zhong
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities , Kunming , 650500 , China.
J Asian Nat Prod Res. 2013 Sep;15(9):979-84. doi: 10.1080/10286020.2013.822368. Epub 2013 Aug 5.
Two new flavanes, (2R)-4'-hydroxy-2',5,7-trimethoxyflavane (1) and (2R,4R)-2',4'-dihydroxy-5,7-dimethoxyflavan-4-ol (2), were isolated from Uraria clarkei, together with two known compounds 5,7-dimethoxy-4'-hydroxyflavan (3) and 5,7,4'-trimethoxyflavan (4). The structures of the new flavanes were characterized by analyses of the MS, IR, UV, CD, 1D, and 2D NMR data. Cytotoxicity test suggested that compounds 1-4 possessed slight activity against K-562 and Hela cell lines, with the IC50 values ranging from 26.6 to 56.3 μM.
从克拉克鱼藤中分离出两种新的黄烷类化合物，即(2R)-4'-羟基-2',5,7-三甲氧基黄烷（1）和(2R,4R)-2',4'-二羟基-5,7-二甲氧基黄烷-4-醇（2），以及两种已知化合物5,7-二甲氧基-4'-羟基黄烷（3）和5,7,4'-三甲氧基黄烷（4）。通过对质谱、红外光谱、紫外光谱、圆二色光谱、一维和二维核磁共振数据的分析对新黄烷类化合物的结构进行了表征。细胞毒性试验表明，化合物1-4对K-562和Hela细胞系具有轻微活性，IC50值范围为26.6至56.3μM。
