来自冬青属植物的两种罕见具有七元环的三萜酸 A 和 B。

Ilelic acids A and B, two unusual triterpenes with a seven-membered ring from Ilex latifolia.

机构信息

Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

出版信息

Org Lett. 2012 Aug 17;14(16):4102-5. doi: 10.1021/ol301745b. Epub 2012 Jul 26.

Abstract

Two unusual triterpenes, ilelic acids A (1) and B (2), together with their biosynthetic related compounds ilelic acids C (3) and D (4) were isolated from the leaves of Ilex latifolia. Their structures with absolute configurations were elucidated by spectroscopic analysis and modified Mosher's method. The plausible biogenetic pathway of 1 and 2 is proposed. These triterpenes exhibited a potent inhibitory effect on MCF-7 and MDA-MB-231 cells.

摘要

从冬青属植物的叶子中分离得到了两种不常见的三萜酸，即石蒜酸 A（1）和 B（2），以及它们的生物合成相关化合物石蒜酸 C（3）和 D（4）。通过光谱分析和改进的 Mosher 方法确定了它们的结构和绝对构型。提出了 1 和 2 的可能生物合成途径。这些三萜酸对 MCF-7 和 MDA-MB-231 细胞具有很强的抑制作用。