Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Marañón, c/Ibiza 43, 28009, Madrid, Spain.
Eur Arch Psychiatry Clin Neurosci. 2010 Apr;260(3):225-33. doi: 10.1007/s00406-009-0046-9. Epub 2009 Sep 19.
The aims of this study were to examine the nature and extent of cognitive impairment in first-episode early-onset psychosis (FE-EOP) soon after their stabilisation and to search for potential differences according to specific diagnostic sub-groups of patients. As part of a Spanish multicentre longitudinal study, 107 FE-EOP patients and 98 healthy controls were assessed on the following cognitive domains: attention, working memory, executive functioning, and verbal learning and memory. Three diagnostic categories were established in the patient sample: schizophrenia (n = 36), bipolar disorder (n = 19), and other psychosis (n = 52). Patients performed significantly worse than controls in all cognitive domains. The three diagnostic sub-groups did not differ in terms of impaired/preserved cognitive functions or degree of impairment. FE-EOP patients show significant cognitive impairment that, during this early phase, seems to be non-specific to differential diagnosis.
本研究旨在探究首发早发性精神分裂症（FE-EOP）患者在病情稳定后即刻认知损伤的性质和程度，并根据患者的特定诊断亚组探寻潜在差异。作为西班牙多中心纵向研究的一部分，107 名 FE-EOP 患者和 98 名健康对照者在以下认知领域接受了评估：注意力、工作记忆、执行功能以及言语学习和记忆。在患者样本中建立了三个诊断类别：精神分裂症（n = 36）、双相情感障碍（n = 19）和其他精神病（n = 52）。与对照组相比，患者在所有认知领域的表现均明显更差。这三个诊断亚组在受损/保留的认知功能或损伤程度方面没有差异。FE-EOP 患者表现出明显的认知损伤，在这一早期阶段，似乎无法针对鉴别诊断进行具体区分。
