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金露梅(Prosopis cineraria(L.)Druce)对艾氏腹水癌荷瘤小鼠的抗肿瘤活性。

Antitumour activity of Prosopis cineraria (L.) Druce against Ehrlich ascites carcinoma-induced mice.

机构信息

Department of Pharmacognosy, Maharaji College of Pharmacy, Chennai 600090, Tamil Nadu, India.

出版信息

Nat Prod Res. 2011 Apr;25(8):857-62. doi: 10.1080/14786419.2010.536159.

DOI:10.1080/14786419.2010.536159
PMID:21462080
Abstract

The antitumour activity of the hydroalcoholic extract of the leaf (PCL) and stem bark (PCB) of Prosopis cineraria (L.) in Swiss albino mice was evaluated against an Ehrlich ascites carcinoma (EAC) tumour model. The activity was assessed using survival time, peritoneal cells, haematological studies, lipid peroxidation, antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, solid tumour mass and in vitro cytotoxicity. PCL and PCB were found to be potent and possessed significant cytotoxicity towards EAC tumour cells.

摘要

评价了智利叶槐(Prosopis cineraria(L.))叶和茎皮的水醇提取物(PCL 和 PCB)对艾氏腹水癌(EAC)肿瘤模型的抗肿瘤活性。使用生存时间、腹腔细胞、血液学研究、脂质过氧化、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽 S-转移酶、实体瘤质量和体外细胞毒性等抗氧化酶来评估活性。PCL 和 PCB 被发现具有强大的活性,并对 EAC 肿瘤细胞具有显著的细胞毒性。

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