Group of Bromatology, Center of Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548 Coimbra, Portugal.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Oct;26(10):1411-20. doi: 10.1080/02652030903107914.
A survey on the occurrence of ochratoxin A (OTA) in 41 bread samples was carried out in the Portuguese capital, Lisbon. Maize (5) and wheat bread (36) and 43 representative urine samples from the Lisbon region were assayed for OTA levels using immunoaffinity column cleanup (IAC) and HPLC with fluorimetric detection (LC–FD). The percentage of OTA-positive samples was slightly higher for maize bread (80%) than wheat bread (70.8%), although, due to its higher consumption, the latter contributes more to OTA exposure, featuring a higher estimated daily intake (EDI). In the urine samples analyzed, both female and male residents displayed similarly high levels of OTA frequency and average contamination. In summary, OTA is a food contaminant of concern and may constitute a hazard for public health through consumption of cereal-based products.
对葡萄牙首都里斯本的 41 份面包样本中赭曲霉毒素 A（OTA）的发生情况进行了调查。使用免疫亲和柱净化（IAC）和带有荧光检测的高效液相色谱法（LC-FD），对来自里斯本地区的 43 份代表性尿液样本中的玉米（5）和小麦面包（36）和 OTA 水平进行了检测。尽管由于其更高的消费量，后者对 OTA 暴露的贡献更大，具有更高的估计每日摄入量（EDI），但玉米面包（80%）的 OTA 阳性样本比例略高于小麦面包（70.8%）。在所分析的尿液样本中，女性和男性居民的 OTA 频率和平均污染水平均较高。总之，OTA 是一种令人关注的食品污染物，通过食用谷物制品，可能对公众健康构成危害。
