血液、母乳和尿液：赭曲霉毒素A暴露的潜在生物标志物及估计每日摄入量：综述
Blood, breast milk and urine: potential biomarkers of exposure and estimated daily intake of ochratoxin A: a review.
作者信息
Soto Julia Bellver, Ruiz María-José, Manyes Lara, Juan-García Ana
机构信息
a Public Health Research Center , Alzira , Spain.
b Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy , University of Valencia , Valencia , Spain.
出版信息
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33(2):313-28. doi: 10.1080/19440049.2015.1118160. Epub 2015 Dec 23.
The purposes of this review are to study potential biomarkers of exposure for ochratoxin A (OTA) in biological fluids (blood, urine and breast milk) for the period 2005-14, calculate the estimated daily intake (EDI) of OTA by using database consumption for the Spanish population, and, finally, to correlate OTA levels detected in blood and EDI values calculated from food products. The values of OTA detected in potential biomarkers of exposure for blood, breast milk and urine ranged from 0.15 to 18.0, from 0.002 to 13.1, and from 0.013 to 0.2 ng ml(-1), respectively. The calculated EDI for OTA in plasma ranged from 0.15 to 26 ng kg(-1) bw day(-1), higher than that obtained in urine (0.017-0.4 ng kg(-1) bw day(-1)). All these values are correlated with the range of EDI for OTA calculated from food products: 0.0001-25.2 ng kg(-1) bw day(-1).
本综述的目的是研究2005年至2014年期间生物体液（血液、尿液和母乳）中赭曲霉毒素A（OTA）暴露的潜在生物标志物，利用西班牙人群的数据库消费量计算OTA的估计每日摄入量（EDI），最后，将血液中检测到的OTA水平与食品计算得出的EDI值进行关联。在血液、母乳和尿液的潜在暴露生物标志物中检测到的OTA值分别为0.15至18.0、0.002至13.1和0.013至0.2 ng ml⁻¹。血浆中OTA的计算EDI范围为0.15至26 ng kg⁻¹ bw day⁻¹，高于尿液中获得的值（0.017至0.4 ng kg⁻¹ bw day⁻¹）。所有这些值都与从食品计算得出的OTA的EDI范围相关：0.0001至25.2 ng kg⁻¹ bw day⁻¹。
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