Department of Epidemiology, Graduate School of Public Health, Pittsburgh, University of Pittsburgh, PA 15213, USA.
Ethn Dis. 2011 Winter;21(1):79-84.
Vitamin D deficiency is highly prevalent worldwide, and is linked to several major chronic, inflammatory and autoimmune diseases. Vitamin D deficiency has not been evaluated in dark skinned individuals living in areas of high sun exposure utilizing more reliable mass spectrometry assay techniques. We determined the prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency in Afro-Caribbean men on the tropical island of Tobago, where there is a high level of sunshine year round. Serum 25(OH)D2 and 25(OH)D3 metabolites were measured following extraction and purification using liquid chromatography and tandem mass spectrometry in 424 Afro-Caribbean men aged > 65 years from a larger population-based cohort study. The mean (+/- SD) serum total 25(OH)D concentration was 35.1 +/- 8.9 ng/mL. Deficiency (< 20 ng/mL) was present in only 2.8% and insufficiency (< 30 ng/mL) in 24% of the men. Multiple linear regression analysis identified age, BMI and daily vitamin D supplementation as the independent correlates of 25(OH)D. None of the men who consumed fish more than once per week had vitamin D deficiency, compared to 4% of the men who consumed fish once per week or less (P = .01, adjusted for age, BMI, and daily vitamin D supplementation). In conclusion, vitamin D deficiency is very uncommon in this Afro-Caribbean population. Longitudinal studies are needed to delineate the possible effects of high vitamin D levels in this population on major diseases hypothesized to be associated with vitamin D deficiency.
维生素 D 缺乏症在全球范围内普遍存在，与几种主要的慢性炎症性和自身免疫性疾病有关。在利用更可靠的质谱分析技术评估生活在高阳光暴露地区的深色皮肤个体的维生素 D 缺乏症方面，尚未进行评估。我们在热带多巴哥岛上确定了非洲裔加勒比男性中 25-羟维生素 D（25(OH)D）缺乏症的流行率，该岛全年阳光充足。在较大的基于人群的队列研究中，从 424 名年龄> 65 岁的非洲裔加勒比男性中提取和纯化血清 25(OH)D2 和 25(OH)D3 代谢物后，使用液相色谱和串联质谱法测量血清 25(OH)D2 和 25(OH)D3 代谢物。平均（+/- SD）血清总 25(OH)D 浓度为 35.1 +/- 8.9 ng/mL。只有 2.8%的男性存在缺乏症（< 20 ng/mL），24%的男性存在不足症（< 30 ng/mL）。多元线性回归分析确定年龄、BMI 和每日维生素 D 补充剂是 25(OH)D 的独立相关因素。每周食用鱼超过一次的男性中没有维生素 D 缺乏症，而每周食用鱼一次或更少的男性中则有 4%患有维生素 D 缺乏症（P =.01，经年龄、BMI 和每日维生素 D 补充剂调整）。综上所述，在这个非洲裔加勒比人群中，维生素 D 缺乏症非常罕见。需要进行纵向研究，以阐明该人群中高维生素 D 水平对假设与维生素 D 缺乏症相关的主要疾病的可能影响。
