Hwang J, Zmuda J M, Kuipers A L, Bunker C H, Santanasto A J, Wheeler V W, Miljkovic I
Iva Miljkovic, MD, PhD, FAHA, Associate professor, Department of Epidemiology, University of Pittsburgh, A524 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA 15261, Phone: 412-624-7325, E-mail:
J Frailty Aging. 2019;8(3):131-137. doi: 10.14283/jfa.2018.40.
Prospective studies examining the potential association of vitamin D with age-related muscle loss have shown inconsistent results.
To examine the association between baseline serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and prospective change in lean mass with aging in African ancestry population. We also determined if associations were modulated by age and diabetes mellitus (DM).
Prospective observational cohort study.
Data were collected from a random sub-sample of 574 men, participants of the Tobago Bone Health Study (TBHS).
574 Afro-Caribbean men, aged 43+ years (mean age: 59.1 ± 10.5), who were randomly selected as the participants in both the baseline and the follow-up visits.
Baseline fasting serum 25(OH)D was measured using liquid chromatography mass spectrometry (LC-MS/MS), and and 1,25(OH)2D was measured using radioimmunosassay (RIA). Changes in dual-energy X-ray absorptiometry (DXA)-measured appendicular lean mass (ALM), and total body lean mass (TBLM) were measured over an average of 6.0 ± 0.5 years. The associations of 25(OH)D and 1,25(OH)2D with ALM and TBLM were assessed by multiple linear regression model after adjusting for potential confounders.
When stratifying all men into two groups by age, greater baseline 25(OH)D and 1,25(OH)2D levels were associated with smaller losses of ALM and TBLM in older (age 60+ years) but not in younger (age 43 - 59 years) men. When stratifying by DM status, the associations of 25(OH)D and 1,25(OH)2D with declines in ALM and TBLM were statistically significant only in prediabetic, but not among normal glycemic or diabetic men.
Higher endogenous vitamin D concentrations are associated with less lean mass loss with aging among older and prediabetic Afro-Caribbean men independent of potential confounders. Our findings raise a possibility that maintaining high serum vitamin D level might be important for musculoskeletal health in elderly and prediabetic African ancestry men.
关于维生素D与年龄相关性肌肉流失潜在关联的前瞻性研究结果并不一致。
研究非洲裔人群中基线血清25-羟维生素D（25(OH)D）、1,25-二羟维生素D（1,25(OH)2D）与随年龄增长的去脂体重的前瞻性变化之间的关联。我们还确定了这些关联是否受年龄和糖尿病（DM）的调节。
前瞻性观察性队列研究。
数据来自多巴哥骨健康研究（TBHS）的574名男性参与者的随机子样本。
574名年龄在43岁及以上（平均年龄：59.1±10.5岁）的非洲裔加勒比男性，他们被随机选为基线和随访访问的参与者。
使用液相色谱-质谱联用（LC-MS/MS）测定基线空腹血清25(OH)D，使用放射免疫分析（RIA）测定1,25(OH)2D。在平均6.0±0.5年的时间里，测量双能X线吸收法（DXA）测定的上肢去脂体重（ALM）和全身去脂体重（TBLM）的变化。在调整潜在混杂因素后，通过多元线性回归模型评估25(OH)D和1,25(OH)2D与ALM和TBLM的关联。
按年龄将所有男性分为两组时，较高的基线25(OH)D和1,25(OH)2D水平与老年（60岁及以上）男性而非年轻（43 - 59岁）男性较小的ALM和TBLM损失相关。按糖尿病状态分层时，25(OH)D和1,25(OH)2D与ALM和TBLM下降的关联仅在糖尿病前期男性中具有统计学意义，在血糖正常或糖尿病男性中则无。
较高的内源性维生素D浓度与老年和糖尿病前期非洲裔加勒比男性随年龄增长较少的去脂体重损失相关，且不受潜在混杂因素影响。我们的研究结果提示，维持较高的血清维生素D水平可能对老年和糖尿病前期非洲裔男性的肌肉骨骼健康很重要。
