Codiţă Irina, Caplan Dana Magdalena, Drăgulescu Elena-Carmina, Lixandru Brînduşa-Elena, Coldea Ileana Luminiţa, Dragomirescu Cristiana Cerasella, Surdu-Bob Cristina, Bădulescu Marius
Cantacuzino" National Institute of Research-Development for Microbiology and Immunology, Bucharest, România.
Roum Arch Microbiol Immunol. 2010 Oct-Dec;69(4):204-12.
Contaminated surfaces are possible vehicles in infection transmission. It is known that both Copper (Cu) and Silver (Ag) efficiently inactivate microbes by direct contact. Aiming at using these metals for benefitting from their antimicrobial effect, but to avoid subsequent toxic effects, we evaluated the antimicrobial activity of nanometric thin Silver and Copper films covering less expensive materials. Using a modified version of the Japan Industrial Standard JIS Z 2801:2000, we demonstrated the antimicrobial activity of the surfaces covered with metal ions nanofilms on microorganisms possibly involved in nosocomial infections and on Bacillus anthracis, bacteria with possible implication in bioterrorist attacks. Copper covered surfaces proved to have better antimicrobial activity than Silver surfaces. Silver covered surfaces showed better activity on Gram negative bacteria than on Gram positive cocci. Going deeper with studies on antimicrobial effects using new methods with better direct and/or functional discriminatory capacity is needed in order to provide additional information on the mechanisms of Silver and Copper nanofilms antimicrobial activity.
受污染的表面可能是感染传播的媒介。已知铜（Cu）和银（Ag）都能通过直接接触有效地使微生物失活。为了利用这些金属的抗菌作用，但又避免随后的毒性作用，我们评估了覆盖在较廉价材料上的纳米银和铜薄膜的抗菌活性。使用日本工业标准JIS Z 2801:2000的修订版，我们证明了覆盖有金属离子纳米膜的表面对可能参与医院感染的微生物以及对炭疽芽孢杆菌（可能与生物恐怖袭击有关的细菌）具有抗菌活性。事实证明，铜覆盖的表面比银覆盖的表面具有更好的抗菌活性。银覆盖的表面对革兰氏阴性菌的活性比对革兰氏阳性球菌的活性更好。为了提供有关银和铜纳米膜抗菌活性机制的更多信息，需要使用具有更好的直接和/或功能区分能力的新方法更深入地研究抗菌作用。
