Monteiro Douglas Roberto, Gorup Luiz Fernando, Takamiya Aline Satie, Ruvollo-Filho Adhemar Colla, de Camargo Emerson Rodrigues, Barbosa Debora Barros
Department of Dental Materials and Prosthodontics, Araçatuba Dental School, São Paulo State University (UNESP), Araçatuba, SP, Brazil.
Int J Antimicrob Agents. 2009 Aug;34(2):103-10. doi: 10.1016/j.ijantimicag.2009.01.017. Epub 2009 Mar 31.
Research has clarified the properties required for polymers that resist bacterial colonisation for use in medical devices. The increase in antibiotic-resistant microorganisms has prompted interest in the use of silver as an antimicrobial agent. Silver-based polymers can protect the inner and outer surfaces of devices against the attachment of microorganisms. Thus, this review focuses on the mechanisms of various silver forms as antimicrobial agents against different microorganisms and biofilms as well as the dissociation of silver ions and the resulting reduction in antimicrobial efficacy for medical devices. This work suggests that the characteristics of released silver ions depend on the nature of the silver antimicrobial used and the polymer matrix. In addition, the elementary silver, silver zeolite and silver nanoparticles, used in polymers or as coatings could be used as antimicrobial biomaterials for a variety of promising applications.
研究已经阐明了用于医疗设备的抗细菌定植聚合物所需的特性。抗生素耐药微生物的增加引发了人们对使用银作为抗菌剂的兴趣。银基聚合物可以保护设备的内表面和外表面免受微生物附着。因此，本综述重点关注各种银形态作为针对不同微生物和生物膜的抗菌剂的作用机制，以及银离子的解离和由此导致的医疗设备抗菌效果的降低。这项工作表明，释放的银离子的特性取决于所使用的银抗菌剂的性质和聚合物基质。此外，用于聚合物或作为涂层的单质银、银沸石和银纳米颗粒可用作抗菌生物材料，用于各种有前景的应用。
