钯催化的手性烯膦配体诱导吲哚和吡咯的不对称烯丙基烷基化反应。
Pd-catalyzed asymmetric allylic alkylation of indoles and pyrroles by chiral alkene-phosphine ligands.
机构信息
Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Lett. 2011 May 6;13(9):2164-7. doi: 10.1021/ol200602x. Epub 2011 Apr 4.
PMID:21462958
Abstract
A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to excellent ee's.
摘要
合成了一系列基于手性联萘酚的末端烯基-膦混合配体，以（S）-BINOL 为起始原料，经过四步反应得到。这些配体被用于钯催化的吲哚和吡咯的对映选择性烯丙基烷基化反应，以高产率和良好到优秀的对映选择性得到所需产物。
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