螺环茚满基磷氮手性配体在吲哚和烯丙基醚的对映选择性钯催化反应中的应用 **解析**：这是一段化学领域的学术性内容，关键词包括“Spiro Indane-Based Phosphine-Oxazolines”（螺环茚满基磷氮手性配体）、“Enantioselective Pd-Catalyzed Allylic Alkylation”（对映选择性钯催化烯丙基烷基化）、“Indoles”（吲哚）、“Allylic Etherification”（烯丙基醚化）等。在翻译时，需要将这些关键词准确地翻译出来，并根据上下文适当调整语序，使译文流畅自然。
Spiro Indane-Based Phosphine-Oxazolines as Highly Efficient P,N Ligands for Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles and Allylic Etherification.
机构信息
State Key laboratory Base of Eco-chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
出版信息
Molecules. 2019 Apr 21;24(8):1575. doi: 10.3390/molecules24081575.
A series of indane-based phosphine-oxazoline ligands with a spirocarbon stereogenic center were examined for palladium-catalyzed asymmetric allylic alkylation of indoles. Under optimized conditions, high yields (up to 98%) and enantioselectivities (up to 98% ee) were obtained with a broad scope of indole derivatives. The ligand was determined to be the most efficient P,N-ligand for this reaction. Moreover, the ligand was also efficient for Pd-catalyzed asymmetric allylic etherification with hard aliphatic alcohols as nucleophiles.
一系列基于茚满的磷-恶唑啉配体具有手性 spiro 碳中心，被用于钯催化吲哚的不对称烯丙基烷基化反应。在优化条件下，具有广泛取代吲哚衍生物的高收率（高达 98%）和对映选择性（高达 98%ee）被获得。该配体被确定为该反应最有效的 P,N-配体。此外，该配体对于 Pd 催化的不对称烯丙基醚化反应也具有较高的效率，硬脂族醇作为亲核试剂。
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