CD4+ 细胞溶解性T细胞克隆赋予对鼠疟的保护作用。
CD4+ cytolytic T cell clone confers protection against murine malaria.
作者信息
Tsuji M, Romero P, Nussenzweig R S, Zavala F
机构信息
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10010.
出版信息
J Exp Med. 1990 Nov 1;172(5):1353-7. doi: 10.1084/jem.172.5.1353.
Abstract
A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
摘要
一个CD4 + T细胞克隆（A1.6）源自用经辐射的子孢子免疫的小鼠的脾细胞。该T细胞克隆识别一种伯氏疟原虫子孢子和血液期共同的抗原，且不同于环子孢子蛋白。克隆A1.6在体外表现出细胞毒性活性，产生IFN-γ和IL-2，并在II类I-Ed分子的背景下识别疟原虫抗原。将该CD4 +克隆被动转移到未免疫的小鼠中可产生高度抗子孢子攻击的保护作用。
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