Dept. of Dermatology, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
Eur J Med Res. 2011 Feb 24;16(2):47-51. doi: 10.1186/2047-783x-16-2-47.
Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited.
To evaluate the response of HIV-infected patients with active syphilis to treatment with penicillin or ceftriaxone. -
A retrospective study involving 24 consecutive patients with a positive Veneral Disease Research Laboratory test (VDRL) and at least one specific treponemal test. 12 patients were treated with different regimens of high-dose penicillin G for at least 2 weeks. Another 12 patients were treated with ceftriaxone 1-2g per day intravenously for 10-21 days. -
After a median follow up of 18,3 months all patients of the penicillin-treated group and 11 of 12 ceftriaxone-treated patients showed a ≥ 4-fold decline in VDRL-titers; 91% of them already within 6 months after therapy. -
Our serological data demonstrate a comparable efficacy of currently recommened penicillin and ceftriaxone treatment regimens for active syphilis in HIV-infected patients.
头孢曲松通常被用作治疗梅毒的替代抗生素药物，但关于其疗效的临床数据有限。
评估 HIV 感染患者使用青霉素或头孢曲松治疗活动性梅毒的反应。
一项回顾性研究，共纳入 24 例 VDRL 检测阳性且至少有一项特异性梅毒螺旋体检测阳性的连续患者。12 例患者接受不同剂量青霉素 G 至少 2 周的治疗方案。另外 12 例患者接受头孢曲松 1-2g/天静脉滴注 10-21 天。
中位随访 18.3 个月后，青霉素治疗组的所有患者和头孢曲松治疗组的 11 例患者的 VDRL 滴度均下降了≥4 倍；其中 91%的患者在治疗后 6 个月内下降。
我们的血清学数据表明，目前推荐的青霉素和头孢曲松治疗方案对 HIV 感染患者的活动性梅毒具有相当的疗效。
