感染 HIV 的梅毒患者对青霉素或头孢曲松静脉注射治疗的反应。
Response of HIV-infected patients with syphilis to therapy with penicillin or intravenous ceftriaxone.
机构信息
Dept. of Dermatology, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
出版信息
Eur J Med Res. 2011 Feb 24;16(2):47-51. doi: 10.1186/2047-783x-16-2-47.
BACKGROUND
Ceftriaxone is commonly used as an alternative antibiotic drug in treating syphilis but clinical data on its efficacy are limited.
OBJECTIVE
To evaluate the response of HIV-infected patients with active syphilis to treatment with penicillin or ceftriaxone. -
METHODS
A retrospective study involving 24 consecutive patients with a positive Veneral Disease Research Laboratory test (VDRL) and at least one specific treponemal test. 12 patients were treated with different regimens of high-dose penicillin G for at least 2 weeks. Another 12 patients were treated with ceftriaxone 1-2g per day intravenously for 10-21 days. -
RESULTS
After a median follow up of 18,3 months all patients of the penicillin-treated group and 11 of 12 ceftriaxone-treated patients showed a ≥ 4-fold decline in VDRL-titers; 91% of them already within 6 months after therapy. -
CONCLUSION
Our serological data demonstrate a comparable efficacy of currently recommened penicillin and ceftriaxone treatment regimens for active syphilis in HIV-infected patients.
背景
头孢曲松通常被用作治疗梅毒的替代抗生素药物，但关于其疗效的临床数据有限。
目的
评估 HIV 感染患者使用青霉素或头孢曲松治疗活动性梅毒的反应。
方法
一项回顾性研究，共纳入 24 例 VDRL 检测阳性且至少有一项特异性梅毒螺旋体检测阳性的连续患者。12 例患者接受不同剂量青霉素 G 至少 2 周的治疗方案。另外 12 例患者接受头孢曲松 1-2g/天静脉滴注 10-21 天。
结果
中位随访 18.3 个月后，青霉素治疗组的所有患者和头孢曲松治疗组的 11 例患者的 VDRL 滴度均下降了≥4 倍；其中 91%的患者在治疗后 6 个月内下降。
结论
我们的血清学数据表明，目前推荐的青霉素和头孢曲松治疗方案对 HIV 感染患者的活动性梅毒具有相当的疗效。
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