University of Pennsylvania School of Medicine, 423 Guardian Drive, 8th floor Blockley, Philadelphia, PA 19104, USA.
Cancer Prev Res (Phila). 2011 Apr;4(4):476-80. doi: 10.1158/1940-6207.CAPR-11-0097.
Relating to the report of Irwin and colleagues in this issue of the journal (beginning on page 522), this perspective discusses exercise training interventions as secondary prevention in breast cancer survivors. Burgeoning observational evidence indicates that prescribing aerobic exercise of 3 hours or more per week could have meaningful mortality and morbidity benefits for breast cancer survivors. Adherence to this exercise prescription, however, will require an infrastructure to guide survivors and to address the common clinical treatment sequelae that might interfere with survivors' ability to regularly perform this level of activity (e.g., symptoms related to estrogen deprivation, arthralgias due to aromatase inhibitors, fatigue, lymphedema, chemotherapy-induced peripheral neuropathy, osteoporosis, upper-extremity functional impairments, and overall functional decline). On the basis of cardiac rehabilitation, a model is proposed to integrate exercise prescription into breast cancer survivor clinical care, with referral to community-based programs for most women.
关于 Irwin 及其同事在本期杂志（第 522 页开始）上的报告，本观点讨论了运动训练干预作为乳腺癌幸存者的二级预防措施。越来越多的观察证据表明，规定每周进行 3 小时或以上的有氧运动可能会对乳腺癌幸存者的死亡率和发病率产生有意义的影响。然而，要遵守这一运动处方，就需要有一个基础设施来指导幸存者，并解决可能干扰幸存者定期进行这种水平活动的常见临床治疗后遗症（例如，与雌激素缺乏相关的症状、芳香酶抑制剂引起的关节痛、疲劳、淋巴水肿、化疗引起的周围神经病、骨质疏松症、上肢功能障碍和整体功能下降）。基于心脏康复，提出了一个模型，将运动处方纳入乳腺癌幸存者的临床护理中，大多数女性都被转介到社区项目中。
