Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.
Cancer Prev Res (Phila). 2011 Apr;4(4):481-5. doi: 10.1158/1940-6207.CAPR-10-0358.
It long has been suspected that psychosocial factors affect cancer development and progression. Although the connections between stress and cancer causation are not strong, epidemiologic and clinical studies have provided strong links between cancer progression and several stress-related factors including chronic stress, depression, and social isolation. Recent molecular and biological studies have identified specific signaling pathways that influence cancer growth and metastasis. In particular, stress hormones can have a significant impact on protecting cancer cells from undergoing the anoikis form of programmed cell death, thus, providing a mechanistic advantage for metastasis. This review provides an overview of the relationship between psychosocial factors and the avoidance of anoikis by cancer cells.
长期以来，人们一直怀疑心理社会因素会影响癌症的发生和发展。尽管压力与癌症之间的联系并不紧密，但流行病学和临床研究已经为癌症的进展与几种与压力相关的因素之间的联系提供了有力的证据，这些因素包括慢性压力、抑郁和社会隔离。最近的分子和生物学研究已经确定了影响癌症生长和转移的特定信号通路。特别是，应激激素可能会对保护癌细胞免于发生细胞凋亡的程序性细胞死亡形式产生重大影响，从而为转移提供了一种机制优势。这篇综述概述了心理社会因素与癌细胞逃避细胞凋亡之间的关系。
