Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
J Cell Biochem. 2018 Mar;119(3):2484-2491. doi: 10.1002/jcb.26363. Epub 2017 Sep 12.
Anoikis is known as a special type of programmed cell death which occurs in response to loss of correct cell-extracellular matrix (ECM) connections. This process could be as pivotal event in normal development and tissue homeostasis and found as important mechanism in cancer invasiveness and metastasis. The persistent infection with oncoviruses including EBV (Epstein Bar virus), HPV (Human Papillomaviruses), HBV (Hepatitis B virus), KSHV (Human herpesvirus 8), HTLV-1 (Human T-lymphotropic virus-1), and HCV (Hepatitis C virus) accounted as one of main risk factor for cancer progression. Some of them play critical roles in metastasis, especially in anoikis resistance which could contribute to metastasis of tumor cells. The better understanding of effects of oncoviruses on anoikis could contribute to finding of effective therapeutic platforms for treatment of virus-associated cancers. This paper highlighted effects of these oncoviruses on anoikis protection in cancer.
失巢凋亡是一种特殊的程序性细胞死亡，发生于细胞与细胞外基质（ECM）连接丢失时。该过程在正常发育和组织稳态中发挥关键作用，也是癌症侵袭和转移的重要机制。持续性的致癌病毒感染，包括 EBV（Epstein Bar virus）、HPV（Human Papillomaviruses）、HBV（Hepatitis B virus）、KSHV（Human herpesvirus 8）、HTLV-1（Human T-lymphotropic virus-1）和 HCV（Hepatitis C virus），是癌症进展的主要危险因素之一。其中一些病毒在转移中发挥关键作用，特别是在失巢凋亡抵抗中，这可能有助于肿瘤细胞的转移。更好地了解致癌病毒对失巢凋亡的影响，有助于寻找治疗病毒相关性癌症的有效治疗平台。本文重点介绍了这些致癌病毒对癌症中失巢凋亡保护的影响。
