Li Ji, Xie Hongfu, Yi Mei, Peng Lefang, Lei Dan, Chen Xiang, Jian Dan
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Mar;36(3):203-11. doi: 10.3969/j.issn.1672-7347.2011.03.003.
To investigate the role of cyclophilin A (CypA) and CD147 in the process of skin aging.
Twenty cases of tissue samples from junior group(<15 years old), middle age group(30-40 years old)or old age group (>65 years old) were collected from photophobic and exposal parts of skin, respectively. Immunohistochemistry (IHC) and in situ hybridization (ISH) were carried out to semi-quantitatively detect the expression level of CyPA and CD147.
IHC demonstrated that both CyPA and CD147 were expressed in both photophobic and exposal parts of normal human skin in all 3 groups. The expression levels of both CyPA and CD147 were increased with increase in age. There were significant differences in both CyPA and CD147 expression among 3 groups (P<0.05). CyPA and CD147 were also positively correlated in all 3 groups. Similar results were achieved by ISH.
The interaction between CD147 and CyPA might play an important role in the process of skin aging.
