Dougherty T J, Cooper M T, Mang T S
Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263.
Lasers Surg Med. 1990;10(5):485-8. doi: 10.1002/lsm.1900100514.
Incidence of cutaneous phototoxic reactions induced by intravenous injection of Photofrin polyporphyrin was assessed in a series of 180 patients (266 injections) undergoing photodynamic therapy (PDT) at Roswell Park Cancer Institute during the period 1986-1989. In addition to the usual verbal questions regarding phototoxic reactions solicited at follow-up, forty-two patients in this group also responded to a written questionnaire designed to solicit answers to specific questions. Photofrin doses ranged from 0.5 to 2.0 mg/kg. Overall, 20-40% of patients reported some type of phototoxic response.
1986年至1989年期间，在罗斯威尔公园癌症研究所对180例接受光动力疗法（PDT）的患者（共进行了266次注射）进行了评估，以确定静脉注射卟吩姆钠多卟啉引发皮肤光毒性反应的发生率。除了在随访时询问有关光毒性反应的常见口头问题外，该组中的42名患者还对一份旨在征求特定问题答案的书面问卷做出了回应。卟吩姆钠的剂量范围为0.5至2.0mg/kg。总体而言，20%至40%的患者报告了某种类型的光毒性反应。
