Wooten R S, Smith K C, Ahlquist D A, Muller S A, Balm R K
Department of Medicine, Mayo Clinic, Rochester, MN 55905.
Lasers Surg Med. 1988;8(3):294-300. doi: 10.1002/lsm.1900080312.
Hematoporphyrin derivative (HpD) is a photoactive, oncophilic substance that produces cutaneous photosensitivity as its only significant side effect. Twenty-three patients who received systemic HpD and the usual light-avoidance precautions were studied prospectively to determine the incidence and severity of cutaneous phototoxicity (CP). Seventeen of the 23 patients (74%) reported CP, including three patients (18%) who experienced blister formation. Symptoms of CP occurred for a mean duration of 6 weeks (range 5-23 weeks). Lack of compliance with restrictive photoprotective measures was felt to be a major contributing factor. Other HpD-related complications included skin hyperpigmentation, ocular discomfort, pruritus, pain at injection site, and urticaria. CP and the restrictive measures to avoid it represent major disadvantages of the clinical use of HpD.
血卟啉衍生物（HpD）是一种光敏性亲肿瘤物质，其唯一显著的副作用是引起皮肤光敏感性。对23例接受全身HpD治疗并采取常规避光预防措施的患者进行了前瞻性研究，以确定皮肤光毒性（CP）的发生率和严重程度。23例患者中有17例（74%）报告发生了CP，其中3例（18%）出现水疱形成。CP症状平均持续6周（范围为5 - 23周）。人们认为未遵守严格的光保护措施是一个主要促成因素。其他与HpD相关的并发症包括皮肤色素沉着、眼部不适、瘙痒、注射部位疼痛和荨麻疹。CP以及避免CP的严格措施是临床使用HpD的主要缺点。
