Department of NMR, All India Institute of Medical Sciences, New Delhi, India.
NMR Biomed. 2011 Dec;24(10):1408-13. doi: 10.1002/nbm.1705. Epub 2011 Apr 4.
This study reports in vivo MRS findings in 11 patients with histologically diagnosed central neurocytomas, which are rare intraventricular tumors of neuronal origin. Single-voxel (1)H MRS was carried out prior to surgery using a point-resolved spectroscopy sequence with TR=6 s, TE=135 ms and 128 scans. In vitro high-resolution (1)H spectroscopy was also carried out on two surgically excised samples. The striking features of the spectra from the central neurocytomas were the presence of high glycine, decreased N-acetylaspartate, increased choline and alanine. Retrospective, blind analysis of the spectra by two independent observers correctly identified all but one central neurocytoma based on the presence of glycine. The presence of glycine and prominent choline in the (1)H MR spectrum is a characteristic feature of the central neurocytomas, and could be used to characterize and differentiate them from other brain tumors.
本研究报告了 11 例经组织学诊断为中枢神经细胞瘤的患者的体内 MRS 发现，中枢神经细胞瘤是一种罕见的起源于神经元的脑室肿瘤。在手术前，使用 TR=6 s、TE=135 ms 和 128 次扫描的点分辨波谱序列进行单体素 (1)H MRS。还对两个手术切除的样本进行了体外高分辨率 (1)H 波谱分析。中枢神经细胞瘤光谱的显著特征是存在高甘氨酸、降低的 N-乙酰天冬氨酸、增加的胆碱和丙氨酸。两位独立观察者对光谱进行的回顾性、盲法分析，仅基于甘氨酸的存在，正确识别了所有但一个中枢神经细胞瘤。(1)H MR 光谱中甘氨酸和明显的胆碱的存在是中枢神经细胞瘤的特征性表现，可用于对其进行特征描述和与其他脑肿瘤进行区分。
