Kim D G, Choe W J, Chang K H, Song I C, Han M H, Jung H W, Cho B K
Department of Neurosurgery, Seoul National University College of Medicine, Korea.
Neurosurgery. 2000 Feb;46(2):329-33; discussion 333-4. doi: 10.1097/00006123-200002000-00013.
The authors report on the metabolic features of central neurocytomas observed during in vivo single-voxel proton magnetic resonance spectroscopy.
Volume-selective single-voxel proton magnetic resonance spectroscopy was performed with a 1.5-T unit using a point-resolved spectroscopy sequence (TR/TE = 2000 ms/135 and 270 ms) to obtain spectra of a single 8-cc voxel. The subjects were five patients in the Department of Neurosurgery of Seoul National University Hospital whose central neurocytomas had been diagnosed histologically. The peak intensities of compounds containing choline (Cho), N-acetylaspartate, creatine/phosphocreatine, and lactate were analyzed.
The ratios of Cho to creatine/phosphocreatine and Cho to N-acetylaspartate were significantly higher than ratios in normal brains. A lactate signal was present, and an unidentified signal was also observed at 3.55 ppm, which might have been produced by inositol or glycine.
A combination of the signal at 3.55 ppm and a prominent Cho peak seems to be a characteristic feature of central neurocytomas. Volume-selective single-voxel proton magnetic resonance spectroscopy could provide additional information to aid in diagnosing this condition.
作者报告了在体单体素质子磁共振波谱观察到的中枢神经细胞瘤的代谢特征。
使用1.5-T设备，采用点分辨波谱序列（TR/TE = 2000 ms/135和270 ms）进行体积选择性单体素质子磁共振波谱分析，以获取单个8立方厘米体素的波谱。研究对象为首尔国立大学医院神经外科的5例经组织学诊断为中枢神经细胞瘤的患者。分析了含胆碱（Cho）、N-乙酰天门冬氨酸、肌酸/磷酸肌酸和乳酸的化合物的峰强度。
Cho与肌酸/磷酸肌酸的比值以及Cho与N-乙酰天门冬氨酸的比值显著高于正常脑内的比值。存在乳酸信号，并且在3.55 ppm处还观察到一个未识别信号，可能由肌醇或甘氨酸产生。
3.55 ppm处的信号与突出的Cho峰相结合似乎是中枢神经细胞瘤的特征性表现。体积选择性单体素质子磁共振波谱可为诊断这种疾病提供额外信息。
