Department of Environmental Health, Harvard School of Public Health, Landmark Building, 415 West, 401 Park Dr., Boston, MA 02215, USA.
Environ Health Perspect. 2010 Nov;118(11):1564-70. doi: 10.1289/ehp.0901831.
Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown.
We investigated whether ambient black carbon (BC), a marker for traffic-related particles, is associated with telomere length in the Normative Aging Study (NAS).
Among 165 never-smoking men from the NAS, leukocyte telomere length (LTL) was measured repeatedly approximately every 3 years from 1999 through 2006 using quantitative real-time polymerase chain reaction (qRT-PCR). BC concentration at their residences during the year before each LTL measurement was estimated based on a spatiotemporal model calibrated with BC measurements from 82 locations within the study area.
The median [interquartile range (IQR)] annual moving-average BC concentration was 0.32 (0.20-0.45) microg/m3. LTL, expressed as population-standardized ratio of telomere repeat to single-copy gene copy numbers, had a geometric mean (geometric SD) of 1.25 (1.42). We used linear mixed-effects models including random subject intercepts and adjusted for several potential confounders. We used inverse probability of response weighting to adjust for potential selection bias due to loss to follow-up. An IQR increase in annual BC (0.25 microg/m3) was associated with a 7.6% decrease (95% confidence interval, -12.8 to -2.1) in LTL. We found evidence of effect modification, with a stronger association among subjects > or = 75 years of age compared with younger participants (p = 0.050) and statin medications appearing protective of the effects of BC on LTL (p = 0.050).
Telomere attrition, linked to biological aging, may be associated with long-term exposures to airborne particles, particularly those rich in BC, which are primarily related to automobile traffic.
端粒长度反映生物年龄，与心血管疾病（CVD）的风险呈负相关。环境空气污染与 CVD 有关，但它对端粒长度的影响尚不清楚。
我们研究了环境黑碳（BC）——一种与交通相关颗粒的标志物，是否与规范老化研究（NAS）中的端粒长度有关。
在来自 NAS 的 165 名从不吸烟的男性中，使用定量实时聚合酶链反应（qRT-PCR）从 1999 年到 2006 年每隔大约 3 年重复测量白细胞端粒长度（LTL）。根据在研究区域内 82 个位置进行的 BC 测量校准的时空模型，估算了他们在每次 LTL 测量前一年居住地的 BC 浓度。
年平均移动平均 BC 浓度的中位数[四分位数范围（IQR）]为 0.32（0.20-0.45）μg/m3。LTL 表示端粒重复与单拷贝基因拷贝数的群体标准化比值，几何平均值（几何标准差）为 1.25（1.42）。我们使用包括随机受试者截距的线性混合效应模型，并调整了几个潜在的混杂因素。我们使用响应反概率加权来调整由于随访丢失而导致的潜在选择偏差。BC 年平均增加 0.25μg/m3，与 LTL 降低 7.6%（95%置信区间，-12.8 至-2.1）有关。我们发现存在效应修饰，在年龄大于或等于 75 岁的受试者中，与年轻参与者相比，这种关联更强（p = 0.050），而他汀类药物似乎对 BC 对 LTL 的影响具有保护作用（p = 0.050）。
与生物衰老相关的端粒损耗可能与长期暴露于空气传播颗粒有关，特别是那些富含 BC 的颗粒，这些颗粒主要与汽车交通有关。
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