Nguyen Thanh Tra, Truong Bich Ngan, Doan Thi Mai Huong, Litaudon Marc, Nguyen Van Hung, Do Thi Thao, Chau Van Minh, Pham Van Cuong
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
Bioorg Med Chem Lett. 2017 Apr 15;27(8):1665-1669. doi: 10.1016/j.bmcl.2017.03.014. Epub 2017 Mar 7.
Four new dammarane-type triterpenoids (1-4) and twelve known compounds (5-16) were isolated from the leaves of Viburnum sambucinum Reinw. ex Blume. Their structures were determined by spectral data analysis, including MS and 2D NMR. Cytotoxic activity evaluation in vitro against four cancer cell lines (KB, LU-1, HepG2 and MCF7) suggested that the octanor-dammarane derivatives were the main cytotoxic components of the leaves of V. sambucinum.
从接骨木叶荚蒾（Viburnum sambucinum Reinw. ex Blume）的叶子中分离得到了4个新的达玛烷型三萜化合物（1-4）和12个已知化合物（5-16）。通过光谱数据分析，包括质谱和二维核磁共振，确定了它们的结构。对4种癌细胞系（KB、LU-1、HepG2和MCF7）的体外细胞毒性活性评估表明，八降达玛烷衍生物是接骨木叶荚蒾叶子的主要细胞毒性成分。
